In-line measurements of the physical and thermodynamic properties of single and multicomponent liquids
Authors: Hugo Bissig, Oliver Büker, Emmelyn Graham, Leslie Wales, Andreia Furtado, Sara Moura, Zoe Metaxiotou, Seok Hwan Lee, Sabrina Kartmann, Jarno Groenesteijn and Joost C. Lötters
Abstract
Microfluidic devices are becoming increasingly important in various fields of pharmacy, flow chemistry and healthcare. In the embedded microchannel, the flow rates, the dynamic viscosity of the transported liquids and the fluid dynamic properties play an important role. Various functional auxiliary components of microfluidic devices such as flow restrictors, valves and flow meters need to be characterised with liquids used in several microfluidic applications. However, calibration with water does not always reflect the behaviour of the liquids used in the different applications. Therefore, several National Metrology Institutes (NMI) have developed micro-pipe viscometers for traceable inline measurement of the dynamic viscosity of liquids used in flow applications as part of the EMPIR 18HLT08 MeDDII project. These micro-pipe viscometers allow the calibration of any flow device at different flow rates and the calibration of the dynamic viscosity of the liquid or liquid mixture used under actual flow conditions. The validation of the micro-pipe viscometers has been performed either with traceable reference oils or with different liquids typically administered in hospitals, such as saline and/or glucose solutions or even glycerol-water mixtures for higher dynamic viscosities. Furthermore, measurement results of a commercially available device and a technology demonstrator for the inline measurement of dynamic viscosity and density are presented in this paper.
Link to the document
(nur in Englisch verfügbar)
Other articles that might interest you
Wink of Knowledge: Measurement of the hydrogen peroxide concentration in water with <0.025% measurement uncertainty
Density measurements of hydrogen peroxide in water with the VLO-M2 were correct within <0.05 kg/m3 using control measurements from a laboratory analyser. The measured deviations correspond to a measurement uncertainty of <0.025% (250ppm) for the concentration determination.
Wink of Knowledge: High Density Media – DLO Density Meter for Liquids
Wink of Knowledge: High Density Media - DLO Density Meter for LiquidsVolume 2 | Number 3Why this test?The measurements carried out show that our DLO...
Wink of knowledge: Ethylene Glycol-Water – VLO
Wink of knowledge: Ethylene Glycol-Water Mixture - VLO Density and Viscosity Meter for Liquids Volume 2 | Number 1 Why this test? The measurements...